Recent Trends of Antimicrobial Agents for Oral Pathogens
이기호,
소속 상세정보
이기호 ( Lee Gi-Ho ) - Dankook University College of Dentistry Department of Oral Medicine
KMID : 1157520130090030185
Abstract
Biofilm of infectious pathogens is associated with acute and chronic disease. Since the bacteria in biofilm express distinct properties from planktonic bacteria, the biofilm is resistance against antibiotics or antimicrobial agents. The bactericidal con-centration of antibiotics for biofilm bacteria may be up to 100-1,000 fold higher compared to planktonic bacteria. Therefore, the failure of antibiotic treatments for bacterial infections has occasionally occurred. It may need development of anti-microbial agents for inhibition or dispersal of the biofilms. In this review of the literature, we introduce characterizations and the resistant mechanism of bacterial biofilm for antimicrobial agents. Also, it summarized current trends for therapeutic anti-biotics and suggested new approaches for development of antimicrobial agents. The studies on biofilm for therapeutic agents are is in its infancy. Thus, the summary of the introduction and the characterization of the biofilm may provide help for the development of antimicrobial agents and improve therapies.
키워드
antimicrobial drug development; antibiotic resistance; oral biofilm; quorum sensing
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